Science2013-09-05 2:56 AM

Unconventional Secretion, Unconventional Solutions

Most eukaryotic secretory proteins are directed into the endoplasmic reticulum (ER) by an amino-terminal signal peptide (leader sequence) and progress to the cell surface through vesicular flow via the Golgi apparatus (1, 2). However, many claims have been made for a number of diverse membrane and soluble proteins that lack a typical signal peptide being transported from the cytoplasm or nucleus independently of this classical ER-Golgi route, so-called unconventional secretion (3–5). Some examples, such as secretion of the yeast a-factor mating pheromone by a plasma membrane peptide transporter (6), are well understood. However, other examples are of proteins that are inefficiently secreted, and the concern is that in some experiments this “export” is due to cell lysis rather than actual secretion (7). Here we summarize the key evidence for unconventional secretion, and pose questions that remain to be addressed.

KEYWORDS

SHARE & LIKE

COMMENTS

ABOUT THE AUTHOR

Science

Science Magazine

0 Following 13 Fans 0 Projects 236 Articles

SIMILAR ARTICLES

AbstractThe conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical funct

阅读更多

IntroductionInitiation of protein synthesis is a key step in the control of gene expression. In eukaryotes, initiation is a highly complex process that

阅读更多

Abstract For decades, social psychological theories have posited that the automatic processes captured by implicit measures have implications for soci

阅读更多

论文摘要动物界最复杂的眼睛可以在物种口足类甲壳动物(濑尿虾)中找到,其中一些有12种不同类型的光感受器,每种各取样较窄的一组波长,范围包含了深紫外光到远红光(300到720纳米)。在功能上,这种彩色复杂性被视作是谜。当3种或4种色彩通道对色彩辨认来说已经足够时,为何要使用12种色彩通道?对口足类动物行

阅读更多

IntroductionCensorship has a long history in China, extending from the efforts of Emperor Qin to burn Confucian texts in the third century BCE to the c

阅读更多

Many animals, on air, water, or land, navigate in three-dimensional (3D) environments, yet it remains unclear how brain circuits encode the animal's 3D

阅读更多

Many animals, on air, water, or land, navigate in three-dimensional (3D) environments, yet it remains unclear how brain circuits encode the animal's 3D

阅读更多

Like mammalian neurons, Caenorhabditis elegans neurons lose axon regeneration ability as they age, but it is not known why. Here, we report that let-7

阅读更多

Like mammalian neurons, Caenorhabditis elegans neurons lose axon regeneration ability as they age, but it is not known why. Here, we report that let-7

阅读更多

摘要翻译: 摘要原文: Wave interference is a fundamental manifestation of the superposition principle with numerous applications. Although in conventional op

阅读更多