心理学年度评论2013-09-05 2:57 AM

The Endocannabinoid System and the Brain - Annual Review of Psychology, 64(1):21

ABSTRACT The psychoactive constituent in cannabis, Δ9-tetrahydrocannabinol (THC), was isolated in the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous cannabinoids (anandamide and 2-arachidonoyl glycerol) were identified only 20 to 25 years later. The cannabinoid system affects both central nervous system (CNS) and peripheral processes. In this review, we have tried to summarize research—with an emphasis on recent publications—on the actions of the endocannabinoid system on anxiety, depression, neurogenesis, reward, cognition, learning, and memory. The effects are at times biphasic—lower doses causing effects opposite to those seen at high doses. Recently, numerous endocannabinoid-like compounds have been identified in the brain. Only a few have been investigated for their CNS activity, and future investigations on their action may throw light on a wide spectrum of brain functions.

KEYWORDS

SHARE & LIKE

COMMENTS

ABOUT THE AUTHOR

心理学年度评论

0 Following 14 Fans 0 Projects 179 Articles

SIMILAR ARTICLES

ABSTRACT Using an autobiographical approach, I review several animal and human split-brain studies that have led me to change my long-term view on h

阅读更多

ABSTRACT The psychoactive constituent in cannabis, Δ9-tetrahydrocannabinol (THC), was isolated in the mid-1960s, but the cannabinoid receptors, CB1

阅读更多

ABSTRACT Although synesthesia has been known about for 200 years, it is only in the past decade or so that substantial progress has been made in stu

阅读更多

ABSTRACT Human aesthetic preference in the visual domain is reviewed from definitional, methodological, empirical, and theoretical perspectives. Aes

阅读更多

ABSTRACT How can we ever know, unequivocally, that another person is conscious and aware? Putting aside deeper philosophical considerations about th

阅读更多

How can we ever know, unequivocally, that another person is conscious and aware? Putting aside deeper philosophical considerations about the nature of

阅读更多

Executive functions (EFs) make possible mentally playing with ideas; taking the time to think before acting; meeting novel, unanticipated challenges; r

阅读更多

From the traditional perspective of associative learning theory, the hypothesis linking modifications of synaptic transmission to learning and memory i

阅读更多

Evolutionary psychology is the second wave of the cognitive revolution. The first wave focused on computational processes that generate knowledge about

阅读更多

From an evolutionary perspective, morality is a form of cooperation. Cooperation requires individuals either to suppress their own self-interest or to

阅读更多