普通精神病学纪要2013-09-05 2:57 AM

Toxoplasma gondii Infection and Self-directed Violence in Mothers

Abstract Context: Two studies based on clinical samples have found an association between Toxoplasma gondii infection and history of suicide attempt. To our knowledge, these findings have never been replicated in a prospective cohort study. Objective: To examine whether T gondii– infected mothers have an increased risk of self-directed violence, violent suicide attempts, and suicide and whether the risk depends on the level of T gondii IgG antibodies. Design: Register-based prospective cohort study. Women were followed up from the date of delivery, 1992 to 1995 until 2006. Setting Denmark. Participants: A cohort of 45 788 women born in Denmark whose level of Toxoplasma -specific IgG antibodies was measured in connection with child birth between 1992 and 1995. Main Outcome Measures: Incidence rates of self-directed violence, violent suicide attempts, and suicide in relation to T gondii seropositivity and serointensity. Results: T gondii– infected mothers had a relative risk of self-directed violence of 1.53 (95% CI, 1.27-1.85) compared with noninfected mothers, and the risk seemed to increase with increasing IgG antibody level. For violent suicide attempts, the relative risk was 1.81 (95% CI, 1.13-2.84) and for suicide, 2.05 (95% CI, 0.78-5.20). A similar association was found for repetition of self-directed violence, with a relative risk of 1.54 (95% CI, 0.98-2.39). Conclusion: Women with a T gondii infection have an increased risk of self-directed violence.

KEYWORDS

SHARE & LIKE

COMMENTS

ABOUT THE AUTHOR

普通精神病学纪要

0 Following 1 Fans 0 Projects 84 Articles

SIMILAR ARTICLES

Context Schizophrenic symptoms are linked to a dysfunction of dopamine neurotransmission and the brain reward system. However, it remains unclear whet

Read More

Context Schizophrenic symptoms are linked to a dysfunction of dopamine neurotransmission and the brain reward system. However, it remains unclear whet

Read More

Context Schizophrenia is a common, highly heritable, neurodevelopmental mental illness, characterized by genetic heterogeneity. Objective To ident

Read More

Context Schizophrenia is a common, highly heritable, neurodevelopmental mental illness, characterized by genetic heterogeneity. Objective To ident

Read More

Context Schizophrenia remains a highly disabling disorder, but the specific determinants and pathways that lead to functional impairment are not well

Read More

Context Schizophrenia remains a highly disabling disorder, but the specific determinants and pathways that lead to functional impairment are not well

Read More

Context Iatrogenic obesity caused by atypical antipsychotics increases the rate of death from all causes. Olanzapine is a commonly prescribed atypical

Read More

Context Iatrogenic obesity caused by atypical antipsychotics increases the rate of death from all causes. Olanzapine is a commonly prescribed atypical

Read More

Context Brain-derived neurotrophic factor (BDNF) is suspected of being a causative factor in psychiatric disorders based on case reports or studies in

Read More

Context Brain-derived neurotrophic factor (BDNF) is suspected of being a causative factor in psychiatric disorders based on case reports or studies in

Read More