变态心理学2013-09-05 2:57 AM

A psychophysiological investigation of threat and reward sensitivity in individuals with panic disorder and/or major depressive disorder.

Abstract Heightened sensitivity to threat and reduced sensitivity to reward are potential mechanisms of dysfunction in anxiety and depressive disorders, respectively. However, few studies have simultaneously examined whether these mechanisms are unique or common to these disorders. In this study, sensitivity to predictable and unpredictable threat (measured by startle response during threat anticipation) and sensitivity to reward (measured by frontal electroencephalographic [EEG] asymmetry during reward anticipation) were assessed in 4 groups (N = 191): those with (1) panic disorder (PD) without a lifetime history of depression, (2) major depression (MDD) without a lifetime history of an anxiety disorder, (3) comorbid PD and MDD, and (4) controls. General distress/negative temperament (NT) was also assessed via self-report. Results indicated that PD (with or without comorbid MDD) was uniquely associated with heightened startle to predictable and unpredictable threat, and MDD (with or without comorbid PD) was uniquely associated with reduced frontal EEG asymmetry. Both psychophysiological measures of threat and reward sensitivity were stable on retest approximately 9 days later in a subsample of participants. Whereas the comorbid group did not respond differently on the tasks relative to the PD-only and MDD-only groups, they did report greater NT than these 2 groups (which did not differ from each other). Results suggest that heightened sensitivity to threat and reduced sensitivity to reward may be specific components of PD and MDD, respectively. In addition, relative to noncomorbid depression and PD, comorbid MDD and PD may be characterized by heightened NT, but not abnormal levels of these “specific” components. (PsycINFO Database Record (c) 2013 APA, all rights reserved)

KEYWORDS

SHARE & LIKE

COMMENTS

ABOUT THE AUTHOR

变态心理学

0 Following 8 Fans 0 Projects 27 Articles

SIMILAR ARTICLES

Abstract Previous research has made significant progress elucidating the nature of cognitive biases in emotional disorders. However, less work has foc

Read More

Abstract Depression is associated with protracted despondent mood, blunted emotional reactivity, and dysregulated parasympathetic nervous system (PNS)

Read More

Abstract Heightened sensitivity to threat and reduced sensitivity to reward are potential mechanisms of dysfunction in anxiety and depressive disorder

Read More

Abstract Rumination is a well-established risk factor for the onset of major depression and anxiety symptomatology in both adolescents and adults. Des

Read More

Abstract Many individuals who experience a major depressive episode will subsequently develop recurrent episodes. Although numerous studies have inves

Read More

Abstract The extent to which a specific negative life event (NLE) is a triggering factor for a suicide attempt is unknown. The current study used a ca

Read More

Abstract In its current instantiation in DSM–IV, a diagnosis of generalized anxiety disorder (GAD) requires the presence of excessive and uncontrollab

Read More

Abstract Multi-informant assessments of adult psychopathology often result in discrepancies among informants’ reports. Among 157 adults meeting criter

Read More

Abstract Obsessive–compulsive disorder (OCD) patients show hyperactive performance monitoring when monitoring their own actions. Hyperactive performan

Read More

Abstract Although an attentional bias for threat-relevant cues has been theorized in posttraumatic stress disorder (PTSD), to date empirical demonstra

Read More