美国化学会志(JACS)2013-09-05 2:57 AM

Simple and Sustainable Iron-Catalyzed Aerobic C–H Functionalization of N,N-Dialkylanilines - Journal of the American Chemical Society (ACS Publications)

Iron(III) chloride catalyzes the aerobic oxidation of tertiary anilines, including tetrahydroisoquinolines, to form reactive iminium ion intermediates that undergo Mannich reactions with silyloxyfurans, nitroalkanes, and other nucleophiles to give the corresponding butenolides, nitro compounds, and α-substituted tetrahydroisoquinolines, respectively, in good to excellent yields.

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