神经(NEURON)2013-09-05 2:58 AM

Neuron - A Prestin Motor in Chicken Auditory Hair Cells: Active Force Generation in a Nonmammalian Species

Active force generation by outer hair cells (OHCs) underlies amplification and frequency tuning in the mammalian cochlea but whether such a process exists in nonmammals is unclear. Here, we demonstrate that hair cells of the chicken auditory papilla possess an electromechanical force generator in addition to active hair bundle motion due to mechanotransducer channel gating. The properties of the force generator, its voltage dependence and susceptibility to salicylate, as well as an associated chloride-sensitive nonlinear capacitance, suggest involvement of the chicken homolog of prestin, the OHC motor protein. The presence of chicken prestin in the hair cell lateral membrane was confirmed by immunolabeling studies. The hair bundle and prestin motors together create sufficient force to produce fast lateral displacements of the tectorial membrane. Our results imply that the first use of prestin as a motor protein occurred early in amniote evolution and was not a mammalian invention as is usually supposed.

KEYWORDS

SHARE & LIKE

COMMENTS

ABOUT THE AUTHOR

神经(NEURON)

0 Following 0 Fans 0 Projects 26 Articles

SIMILAR ARTICLES

The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and

Read More

Structure and function of presynaptic terminals are critical for the transmission and processing of neuronal signals. Trans-synaptic signaling systems

Read More

Neural circuits are shaped by activity-dependent elimination of redundant synapses during postnatal development. In many systems, postsynaptic activity

Read More

Although communication between neurons is considered a function of the synapse, neurons also release neurotransmitter from their dendrites. We found th

Read More

Neurotransmitter spillover represents a form of neural transmission not restricted to morphologically defined synaptic connections. Communication betwe

Read More

Benzodiazepines (BZs) allosterically modulate γ-aminobutyric acid type-A receptors (GABAARs) to increase inhibitory synaptic strength. Diazepam binding

Read More

Early stages of visual processing must capture complex, dynamic inputs. While peripheral neurons often implement efficient encoding by exploiting natur

Read More

Recent studies have reported the existence of hippocampal “time cells,” neurons that fire at particular moments during periods when behavior and locati

Read More

Previous studies have shown that neurons in area V4 are involved in the processing of shapes of intermediate complexity and are sensitive to curvature.

Read More

We developed a screening method for orphan receptor ligands, in which cell-surface proteins are expressed in Drosophila embryos from GAL4-dependent ins

Read More