PLOS ONE2013-10-16 9:19 PM

An Evaluation of the Left-Brain vs. Right-Brain Hypothesis with Resting State Functional Connectivity Magnetic Resonance Imaging 对左右大脑静息态下功能连接性假说基于磁共振成像的评价

Abstract Lateralized brain regions subserve functions such as language and visuospatial processing. It has been conjectured that individuals may be left-brain dominant or right-brain dominant based on personality and cognitive style, but neuroimaging data has not provided clear evidence whether such phenotypic differences in the strength of left-dominant or right-dominant networks exist. We evaluated whether strongly lateralized connections covaried within the same individuals. Data were analyzed from publicly available resting state scans for 1011 individuals between the ages of 7 and 29. For each subject, functional lateralization was measured for each pair of 7266 regions covering the gray matter at 5-mm resolution as a difference in correlation before and after inverting images across the midsagittal plane. The difference in gray matter density between homotopic coordinates was used as a regressor to reduce the effect of structural asymmetries on functional lateralization. Nine left- and 11 right-lateralized hubs were identified as peaks in the degree map from the graph of significantly lateralized connections. The left-lateralized hubs included regions from the default mode network (medial prefrontal cortex, posterior cingulate cortex, and temporoparietal junction) and language regions (e.g., Broca Area and Wernicke Area), whereas the right-lateralized hubs included regions from the attention control network (e.g., lateral intraparietal sulcus, anterior insula, area MT, and frontal eye fields). Left- and right-lateralized hubs formed two separable networks of mutually lateralized regions. Connections involving only left- or only right-lateralized hubs showed positive correlation across subjects, but only for connections sharing a node. Lateralization of brain connections appears to be a local rather than global property of brain networks, and our data are not consistent with a whole-brain phenotype of greater “left-brained” or greater “right-brained” network strength across individuals. Small increases in lateralization with age were seen, but no differences in gender were observed. 论文摘要 单侧性大脑区域参与了比如语言和视觉空间处理的功能。我们能根据个人性格和认知方式大概推断出一个人是左脑型还是右脑型,但是神经影像数据仍无法明确证实这种着重于左脑还是右脑网络占主导的表面差异的看法。我们对强单侧性连接在同一个体内是否共变做了评估。我们从公共收集了千余张年龄在7到29岁间个体的静息态扫描,对扫描数据进行了分析。我们给每个个体中的7266个以5毫米分辨率左右覆盖灰质的区域里的每一对进行了功能性偏侧化的检测,来比较图像倒转经过中矢面前后时的变化。同位坐标间灰质密度的差异被作为回归因素来降低结构性不对称在功能性定位上造成的影响。9个左单侧性和11个右单侧性枢纽在来自强单侧性连接图表里的程度图中被标记为峰点。左单侧性枢纽包含了默认活动网络的区域(内侧前额叶皮质,后扣带回皮质,颞顶连接)和语言区域(Broca区和Wernicke区),而右单侧性枢纽包括了来自控制认知网的区域(例如外侧顶内沟,前侧脑岛,MT区,额叶眼动区)。左单侧性和右单侧性枢纽组成了两个单独的相互单侧性区域的网络。仅含左单侧性或右单侧性的连接揭示了个体间的正相关性,但仅指共享单个结点的连接。大脑连接的单侧性看起来更像是大脑网络中的局部特性而非整体性,而且我们的数据与不同个体间左脑型或者右脑型网络外部性强度的全脑表征不一致。我们发现单侧性小幅增长与年龄正相关,但还未发现性别差异对这一增长的影响。

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