Science2014-01-07 10:25 PM

Creating a False Memory in the Hippocampus 海马体创建错误记忆

Abstract Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram–bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were later optically reactivated during fear conditioning in a different context. The DG experimental group showed increased freezing in the original context, in which a foot shock was never delivered. The recall of this false memory was context-specific, activated similar downstream regions engaged during natural fear memory recall, and was also capable of driving an active fear response. Our data demonstrate that it is possible to generate an internally represented and behaviorally expressed fear memory via artificial means. 论文摘要 回忆也有不靠谱时。我们通过光遗传操纵海马体内记忆承载细胞在小鼠脑内创建了一个错误记忆。暴露于特定环境而被激活的齿状回(DG)或CA1区神经元被2型紫红质通道蛋白标记。这些神经元随后在不同环境中的恐惧条件下被光重激活。DG实验组在足部电击从未传递的原始环境中表现出持续增长的冻结。这种虚假记忆的回忆与特定环境有关,激活了参与自然回忆恐惧记忆的类似下游区域,并且还能够引起恐惧反应。我们的数据证实了能运用人工手段产生通过内在表现和行为表达的恐惧记忆的可能性。

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