Science2014-01-07 10:43 PM

Sleep Drives Metabolite Clearance from the Adult Brain 睡眠增进成人大脑中代谢物的清除

Abstract
The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system. 论文摘要 睡眠对所有动物物种的保护说明睡眠具有非常重要的功能。 改研究指出睡眠有保证保证代谢平衡的重要作用。 在活体小鼠上进行四甲基扩散和双光子成像的时实评估,我们发现自然睡眠或者麻醉伴随着60%的细胞间隙的增加, 这导致了脑脊髓间隙液的对流交换的增加。 反过来,间隙液体的对流交换增加了在睡眠过程中对β-淀粉样蛋白的清除。 因此,睡眠的恢复功能也许是因为其加强清除了人体清醒时积聚于中枢神经系统的神经废物。

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