细胞期刊(Cell)2014-01-06 12:54 AM

Evidence that the Lunar Cycle Influences Human Sleep 农历周期影响人类睡眠的证据

Abstract Endogenous rhythms of circalunar periodicity (∼29.5 days) and their underlying molecular and genetic basis have been demonstrated in a number of marine species [1,2]. In contrast, there is a great deal of folklore but no consistent association of moon cycles with human physiology and behavior [3]. Here we show that subjective and objective measures of sleep vary according to lunar phase and thus may reflect circalunar rhythmicity in humans. To exclude confounders such as increased light at night or the potential bias in perception regarding a lunar influence on sleep, we retrospectively analyzed sleep structure, electroencephalographic activity during non-rapid-eye-movement (NREM) sleep, and secretion of the hormones melatonin and cortisol found under stringently controlled laboratory conditions in a cross-sectional setting. At no point during and after the study were volunteers or investigators aware of the a posteriori analysis relative to lunar phase. We found that around full moon, electroencephalogram (EEG) delta activity during NREM sleep, an indicator of deep sleep, decreased by 30%, time to fall asleep increased by 5 min, and EEG-assessed total sleep duration was reduced by 20 min. These changes were associated with a decrease in subjective sleep quality and diminished endogenous melatonin levels. This is the first reliable evidence that a lunar rhythm can modulate sleep structure in humans when measured under the highly controlled conditions of a circadian laboratory study protocol without time cues. 论文摘要 环月周期的内源性节律(约29.5天)和他们潜在的分子和遗传基础已在某些海洋物种中被证明。与此相反,流传着有关月亮周期的民间传说,但仍未发现月亮周期与人体生理和行为间的一致关联。在此我们表明,根据月相和因此反映出的人体内表现出的月运周期节律的有关睡眠的主观和客观评估方法不尽相同。为了排除如夜间光照增加或有关月亮对睡眠影响在感知方面存在的潜在偏见等混杂因素,我们回顾性地分析了睡眠结构,在非快速眼动(NREM)睡眠期的脑电图活动和在截面设定中严格控制的实验室条件下观察到的荷尔蒙褪黑激素和皮质醇分泌。无论研究期间或之后任何时候,志愿者或调查者都意识到了有关月相的后验分析。我们发现,满月前后, 作为深度睡眠的指标之一的NREM睡眠期脑电图(EEG)三角区活动减少了30%,入睡时间延长了5分钟,和脑电图评估的总睡眠时间缩短了20分钟。这些变化与主观睡眠质量减少有关联并减少了内源性褪黑素水平。该首个证据是在无时间暗示的昼夜实验室研究方案的高度受控条件下测得的,这第一次证明了月运节律可以调节人类睡眠结构。

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细胞期刊(Cell)

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