Nature2013-12-27 9:15 PM

Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange 米诺环素,一种小胶质细胞抑制剂,可减少人类经济交换“美人计”风险

Abstract Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the ‘honey trap’ during an economic exchange. Males tend to cooperate with physically attractive females without careful evaluation of their trustworthiness, resulting in betrayal by the female. In this experiment, healthy male participants made risky choices (whether or not to trust female partners, identified only by photograph, who had decided in advance to exploit the male participants). The results show that trusting behaviour in male participants significantly increased in relation to the perceived attractiveness of the female partner, but that attractiveness did not impact trusting behaviour in the minocycline group. Animal studies have shown that minocycline inhibits microglial activities. Therefore, this minocycline effect may shed new light on the unknown roles microglia play in human mental activities. 论文摘要: 近期有报告称,四环素类抗生素米诺环素,能改善精神疾病的症状,并且在健康受试者中有助于作出清醒的决策。我们在此要显示的研究结果是,米诺环素在经济交换过程中还能降低中“美人计”的风险。男性往往倾向于与身体上具有吸引力的女性合作,结果被女性背叛。在本实验中,健康男性受试者作出有风险的选择(无论是否信任女性合作伙伴,这些女性合作者只能通过照片来选择,并且事先都已决定要利用男性合作者)。结果显示,男性受试者的信任行为显著增加与女性合作伙伴的吸引力有关,但这种吸引力也不影响米诺环素组的信任行为。动物研究显示,米诺环素抑制小胶质细胞的活动。因此,米诺环素的这种作用对于小胶质细胞在人类精神活动中的未知作用可能带来新的提示。

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