Nature2014-01-07 11:38 PM

Towards practical, high-capacity, low-maintenance information storage in synthesized DNA 趋向实用,高容量,低维护的合成DNA信息存储

Abstract Digital production, transmission and storage have revolutionized how we access and use information but have also made archiving an increasingly complex task that requires active, continuing maintenance of digital media. This challenge has focused some interest on DNA as an attractive target for information storage because of its capacity for high-density information encoding, longevity under easily achieved conditions and proven track record as an information bearer. Previous DNA-based information storage approaches have encoded only trivial amounts of information or were not amenable to scaling-up, and used no robust error-correction and lacked examination of their cost-efficiency for large-scale information archival. Here we describe a scalable method that can reliably store more information than has been handled before. We encoded computer files totalling 739 kilobytes of hard-disk storage and with an estimated Shannon information of 5.2 × 10^6 bits into a DNA code, synthesized this DNA, sequenced it and reconstructed the original files with 100% accuracy. Theoretical analysis indicates that our DNA-based storage scheme could be scaled far beyond current global information volumes and offers a realistic technology for large-scale, long-term and infrequently accessed digital archiving. In fact, current trends in technological advances are reducing DNA synthesis costs at a pace that should make our scheme cost-effective for sub-50-year archiving within a decade. 论文摘要 数字化生产,传输和存储彻底改变了我们获得和使用信息的方式,但也存档了对数字媒体有活跃,持续的维护需求的日益复杂的任务。这种挑战主要集中在用作信息存储的DNA上,由于其用于高密度的信息编码的容量,在易实现条件下的长活性,以及其作为信息载体已证实的追踪记录都使其成为极具吸引力的目标。以前基于DNA的信息存储方法只编码了微量信息,或对扩大规模无法兼容,且对于大规模信息档案缺乏对其成本效益的检验。在此我们描述了一个可扩展的方法,比起以前掌握的方法,它能够可靠地存储更多信息。我们将共计739千字节硬盘存储和估计5.2×10 ^ 6比特Shannon信息的计算机文件编入一个DNA代码,合成该DNA,对它进行重新排序,并以100%准确度重建原始文件。理论分析表明,我们基于DNA的存储方式规模可以远超目前全球信息量并且为大规模,长期和非经常访问的数字归档提供了一个现实技术。 事实上,目前技术进步的发展趋势正在减少DNA合成成本,且应会在10年内使我们方案在随后50年的存档中具有成本效益。

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