新英格兰医学杂志2014-01-09 12:49 AM

Association of Nut Consumption with Total and Cause-Specific Mortality — NEJM 坚果消费与整体和特因死亡率的关系

Abstract 论文摘要 Background Increased nut consumption has been associated with a reduced risk of major chronic diseases, including cardiovascular disease and type 2 diabetes mellitus. However, the association between nut consumption and mortality remains unclear. 背景 已经表明坚果食用量的增加与包括心血管疾病和2型糖尿病等在内的主要慢性疾病危险降低相关。然而坚果食用量与死亡率之间的相关性仍然不清楚。 Methods We examined the association between nut consumption and subsequent total and cause-specific mortality among 76,464 women in the Nurses' Health Study (1980–2010) and 42,498 men in the Health Professionals Follow-up Study (1986–2010). Participants with a history of cancer, heart disease, or stroke were excluded. Nut consumption was assessed at baseline and updated every 2 to 4 years. 方法 我们对护士健康研究(1980-2010年)中76464名女性和卫生专业人员随访研究(1986-2010年)中42498名男性的坚果食用量与后来的总死亡率和特因死亡率间的相关性进行调查,排除有癌症、心脏病或卒中病史的受试者。基线时评价坚果食用量,每2~4年更新1次。 Results During 3,038,853 person-years of follow-up, 16,200 women and 11,229 men died. Nut consumption was inversely associated with total mortality among both women and men, after adjustment for other known or suspected risk factors. The pooled multivariate hazard ratios for death among participants who ate nuts, as compared with those who did not, were 0.93 (95% confidence interval [CI], 0.90 to 0.96) for the consumption of nuts less than once per week, 0.89 (95% CI, 0.86 to 0.93) for once per week, 0.87 (95% CI, 0.83 to 0.90) for two to four times per week, 0.85 (95% CI, 0.79 to 0.91) for five or six times per week, and 0.80 (95% CI, 0.73 to 0.86) for seven or more times per week (P<0.001 for trend). Significant inverse associations were also observed between nut consumption and deaths due to cancer, heart disease, and respiratory disease. 结果 在3038853人-年的随访期间,16200名女性和11229名男性死亡。无论女性或男性,在校正其他已知或怀疑的危险因素后,坚果食用量与总死亡率呈负相关。与不吃坚果的受试者相比,在吃坚果的受试者中,每周食用坚果少于1次者发生死亡的汇总多变量风险比为0.93[95% 可信区间(CI)为0.90~0.96],每周食用坚果1次者为0.89(95%CI为0.86~0.93),每周食用坚果2~4次者为0.87(95%CI为0.83~0.90),每周食用坚果5或6次者为0.85(95%CI为0.79~0.91),每周食用坚果≥7次者为0.80(95%CI为0.73~0.86)(趋势P值<0.001)。坚果食用量与癌症、心脏病和呼吸疾病所致的死亡间也呈显著负相关。 Conclusions In two large, independent cohorts of nurses and other health professionals, the frequency of nut consumption was inversely associated with total and cause-specific mortality, independently of other predictors of death. (Funded by the National Institutes of Health and the International Tree Nut Council Nutrition Research and Education Foundation.) 结论 在护士和其他卫生专业人员两项大型独立队列中,独立于其他的预测死亡因素,食用坚果的频率与总死亡率和特因死亡率呈负相关。

KEYWORDS

SHARE & LIKE

COMMENTS

ABOUT THE AUTHOR

新英格兰医学杂志

0 Following 0 Fans 0 Projects 8 Articles

SIMILAR ARTICLES

Abstract 论文摘要 Background Many beliefs about obesity persist in the absence of supporting scientific evidence (presumptions); some persist despite

Read More

Abstract BackgroundIn September 2012, the World Health Organization reported the first cases of pneumonia caused by the novel Middle East respiratory

Read More

Abstract 论文摘要 Background Weight loss is recommended for overweight or obese patients with type 2 diabetes on the basis of short-term studies, but lo

Read More

Abstract BackgroundDiabetes is a risk factor for dementia. It is unknown whether higher glucose levels increase the risk of dementia in people withou

Read More

Abstract BackgroundWorldwide, 2.75 billion passengers fly on commercial airlines annually. When in-flight medical emergencies occur, access to care is

Read More

Abstract 论文摘要 Background Increased nut consumption has been associated with a reduced risk of major chronic diseases, including cardiovascular disea

Read More

Abstract Background Recurrent Clostridium difficile infection is difficult to treat, and failure rates for antibiotic therapy are high. We studied

Read More

Abstract 论文摘要 Background Observational cohort studies and a secondary prevention trial have shown an inverse association between adherence to the

Read More