PLOS ONE2013-12-06 1:53 AM

Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966 长期失业与31岁男性体内的短端粒有关:对芬兰北部1966出生群组的调查研究

Abstract Objective Life stress resulting from early-life experiences and domestic stress is linked with shorter leukocyte telomere length (LTL), but evidence on employment-related stress is scarce. We explored whether unemployment in early adulthood is associated with shorter LTL, a potential biomarker of premature aging. 目标 源自早期生活经历和家庭应激的生活压力与白细胞端粒长度较短有关,但是仍然缺乏有关求职压力的证据。我们探讨了早期成年时期失业是否与较短的白细胞端粒长度有关,这一端粒很可能是记录过早衰老的生物性标志物。 Methods We used data from 5620 men and women belonging to the Northern Finland Birth Cohort 1966. Individually registered unemployment days in 1995–97 were compared with data on biological, behavioral and socioeconomic health predictors and existing medical conditions obtained by surveys and clinical examinations at follow-up in 1997–98. Mean LTL at follow-up was measured by multiplex quantitative real-time PCR. We calculated odds ratios and their 95% confidence intervals (CI) of belonging to the sex-stratified shortest decile of standardized relative mean LTL according to the categories of: 0, <260, <500 and over 500 unemployment days, representing 0, <1, <2 and over 2 calendar years. 我们使用来自芬兰北部1966年出生群体中的5620个样本数据,将他们在1995年至1997年间失业的日期单独记录下来且与样本生物,行为和社会经济健康方面所作的预测进行对比,同时进行比较的还有根据1997年和1998年随访所得的调查和临床检查而得到的现存医疗状况。随访所得样本的白细胞端粒均值是通过多重实时定量PCR检测(聚合酶链反应)得出的。我们计算了比值比,按白细胞端粒长度的标准相对均值进行性别抽样,然后按最短十分位进行等分得到95%置信区间(CI),接着计算该置信区间。该置信区间根据失业天数分别等于0,小于260,小于500和多于500天来代表日历年数分别等于0,小于1,小于2和大于2。 Results Among men, unemployment exceeding 500 days during three years was associated with having shorter LTL at follow-up, compared to being continuously employed. The corresponding odds ratio was 2.61 (95% CI 1.16 to 5.85) in the fully adjusted model. Such an association was not found among women in this study. 结果 研究人员在随访中发现,和那些正常上班的男性比,如果男性在三年内失业超过500天,他们会有更短的白细胞端粒长度。相应的比值比在充分调整模型中为2.61%(其95%置信区间为[1.16,5.85])。在受测女性中则未发现相同的对应关系。 Conclusions Long-term unemployment in early adulthood is associated with shorter LTL among men. 早期成年时期长期失业会导致白细胞端粒长度变短。

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