PLOS ONE2014-01-02 11:27 PM

Psychedelics and Mental Health: A Population Study 致幻剂和精神健康:样本研究

The classical serotonergic psychedelics LSD, psilocybin, mescaline are not known to cause brain damage and are regarded as non-addictive. Clinical studies do not suggest that psychedelics cause long-term mental health problems. Psychedelics have been used in the Americas for thousands of years. Over 30 million people currently living in the US have used LSD, psilocybin, or mescaline. 背景 经典的血清素迷幻药LSD, 裸盖菇碱,仙人球毒碱被认为不能导致脑部损伤并且也不会致人成瘾。 临床研究并没有表明其会引起长期的心理健康问题。 致幻剂已经在美洲使用了几千年, 超过3千万的人现在居住在美国已经使用了LSD, 裸盖菇碱,或者仙人球毒碱。

To evaluate the association between the lifetime use of psychedelics and current mental health in the adult population. 目标 为了评估终生服用致幻剂和成年人精神健康的关系。
Data drawn from years 2001 to 2004 of the National Survey on Drug Use and Health consisted of 130,152 respondents, randomly selected to be representative of the adult population in the United States. Standardized screening measures for past year mental health included serious psychological distress (K6 scale), mental health treatment (inpatient, outpatient, medication, needed but did not receive), symptoms of eight psychiatric disorders (panic disorder, major depressive episode, mania, social phobia, general anxiety disorder, agoraphobia, posttraumatic stress disorder, and non-affective psychosis), and seven specific symptoms of non-affective psychosis. We calculated weighted odds ratios by multivariate logistic regression controlling for a range of sociodemographic variables, use of illicit drugs, risk taking behavior, and exposure to traumatic events. 方法 数据来自2001年到2004对130152名受访者进行的全国药物服用和健康调查,这些受访者是在美国随机抽取的成年人代表。 过去一年精神健康标准化筛选措施包括严重的心理困扰(K6级),精神健康治疗(住院,门诊,药物治疗,需要但是没有接受), 八种精神疾病的症状(恐慌症,重度抑郁发作,躁狂症,社交恐惧症,广泛性焦虑症,广场恐怖症,创伤后应激障碍,以及非情感性精神病) ,以及非情感性精神病的7种特别症状。我们通过对一系列的社会人口学变量,非法药物使用,冒险行为,以及暴露于创伤事件等因素进行的Logistic回归控制计算出了加权比值比。
21,967 respondents (13.4% weighted) reported lifetime psychedelic use. There were no significant associations between lifetime use of any psychedelics, lifetime use of specific psychedelics (LSD, psilocybin, mescaline, peyote), or past year use of LSD and increased rate of any of the mental health outcomes. Rather, in several cases psychedelic use was associated with lower rate of mental health problems. 结果 21967个受访者( 13.4 %加权)说明在终生使用迷幻剂。终生使用任何迷幻剂,终生使用特定迷幻剂(LSD, 裸盖菇碱,仙人球毒碱),或者过去一年使用LSD和精神健康问题发生率增多之间没有显著的关系。 相反,在一些情况下,迷幻剂的使用和较低的精神问题发生率相关。
We did not find use of psychedelics to be an independent risk factor for mental health problems. 结论 我们不认为迷幻剂的服用是精神健康问题的一个独立危险因素。






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