PLOS ONE2014-01-12 11:25 PM

Financial Conflicts of Interest and Reporting Bias Regarding the Association between Sugar-Sweetened Beverages and Weight Gain: A Systematic Review of Systematic Reviews 对含糖饮料和体重增加间关系的报告偏倚和利益上的经济冲突:对系统评价的系统评价

Abstract Background Industry sponsors' financial interests might bias the conclusions of scientific research. We examined whether financial industry funding or the disclosure of potential conflicts of interest influenced the results of published systematic reviews (SRs) conducted in the field of sugar-sweetened beverages (SSBs) and weight gain or obesity. 背景 行业赞助商的经济利益可能会使科学研究结论有所偏倚。我们将验证是否工业上的金融资助或潜在利益冲突的披露会影响含糖饮料(SSBs) 和体重增加或肥胖方面进行的系统评价(SRS)已发表的结果。 Methods and Findings We conducted a search of the PubMed, Cochrane Library, and Scopus databases to identify published SRs from the inception of the databases to August 31, 2013, on the association between SSB consumption and weight gain or obesity. SR conclusions were independently classified by two researchers into two groups: those that found a positive association and those that did not. These two reviewers were blinded with respect to the stated source of funding and the disclosure of conflicts of interest. 研究方法和结果 我们搜索了PubMed,Cochrane图书馆,和Scopus数据库来识别从数据库建立初期至2013年8月31日截止范围内已发表的有关含糖饮料消费和体重增加或肥胖之间关系的系统评价(SRs)。系统评价(SR)结论由两位研究人员独立分类成两组:那些发现了正相关性的分为一组,其他无相关性的则分为另已组。这两位评审员均不被告知有关资金声称的来源及利益冲突的披露。 We identified 17 SRs (with 18 conclusions). In six of the SRs a financial conflict of interest with some food industry was disclosed. Among those reviews without any reported conflict of interest, 83.3% of the conclusions (10/12) were that SSB consumption could be a potential risk factor for weight gain. In contrast, the same percentage of conclusions, 83.3% (5/6), of those SRs disclosing some financial conflict of interest with the food industry were that the scientific evidence was insufficient to support a positive association between SSB consumption and weight gain or obesity. Those reviews with conflicts of interest were five times more likely to present a conclusion of no positive association than those without them (relative risk: 5.0, 95% CI: 1.3–19.3). 我们确定了17个SRS(产生有18结论)。在其中6个结论中,有关某些食品行业的利益经济冲突被披露。在这些没有任何已报告利益冲突的评论中,83.3%的结论(10/12)认为含糖饮料的消费可能是引起体重增加的潜在危险因素。与此相反,约83.3%(5/6)相同比例的结论,即这些披露有关食品工业某些利益经济冲突的系统评价的结论认为科学证据不足以支持含糖饮料消费与体重增加或肥胖之间具有正相关性。这些具有利益冲突的评论给出无正相关性结论的可能性是那些无利益冲突结论的5倍。(相对危险度:5.0,95%CI:1.3-19.3)。 An important limitation of this study is the impossibility of ruling out the existence of publication bias among those studies not declaring any conflict of interest. However, the best large randomized trials also support a direct association between SSB consumption and weight gain or obesity. 这项研究的一个重大局限即是这些还未声明任何利益冲突的研究无法排除存在发表偏倚的可能性。然而,最佳大型随机试验也支持含糖饮料消费与体重增加或肥胖之间具有直接关联。 Conclusions Financial conflicts of interest may bias conclusions from SRs on SSB consumption and weight gain or obesity. 结论 经济利益冲突可能引起有关含糖消费和体重增加或肥胖的系统评价结论有所偏倚。

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