PNAS2014-01-15 9:23 PM

被TRAIL包裹的白细胞杀死循环癌细胞 TRAIL-coated leukocytes that kill cancer cells in the circulation 

论文摘要 

在许多的癌症中,癌细胞通过血液的扩散可能会引起在治疗结束后的不良后果。越来越多的证据显示了 selectin蛋白素细胞在癌细胞与血管壁之间粘合作用促进了整个扩散过程,这和在一些炎症中的白血球会转移扩散的原理基本相似。论文描述了一种用来找到并杀死血液结肠癌细胞和前列腺癌细胞的方法,该方法使得白细胞可以瞄准并杀死血液中只对癌症TNF相关的细胞因子,这个因子包含表面的配体(TRAIL)和E-selection蛋白粘合受体。我们用这种特性在人类血液样本和老鼠血液样本中进行试验,我们模拟杀癌细胞存在的细胞毒性环境,同时增加表面积为帮助受体介导的信号的转移。这些研究结果表明,这些“非正常杀伤型细胞”将有希望在血液循环中使肿瘤细胞循环扩散作用变的无效。


Abstract
Metastasis through the bloodstream contributes to poor prognosis in many types of cancer. Mounting evidence implicates selectin-based adhesive interactions between cancer cells and the blood vessel wall as facilitating this process, in a manner similar to leukocyte trafficking during inflammation. Here, we describe a unique approach to target and kill colon and prostate cancer cells in the blood that causes circulating leukocytes to present the cancer-specific TNF-related apoptosis inducing ligand (TRAIL) on their surface along with E-selectin adhesion receptor. This approach, demonstrated in vitro with human blood and also in mice, mimics the cytotoxic activity of natural killer cells and increases the surface area available for delivery of the receptor-mediated signal. The resulting “unnatural killer cells” hold promise as an effective means to neutralize circulating tumor cells that enter blood with the potential to form new metastases. 


KEYWORDS

SHARE & LIKE

COMMENTS

ABOUT THE AUTHOR

PNAS

0 Following 4 Fans 0 Projects 58 Articles

SIMILAR ARTICLES

AbstractIn animal communication research, vocal labeling refers to incidents in which an animal consistently uses a specific acoustic signal when prese

Read More

AbstractWe show that easily accessible digital records of behavior, Facebook Likes, can be used to automatically and accurately predict a range of high

Read More

意义2010年 墨西哥湾北部深水地平线(MC252)灾难泄漏了超过400万桶原油。石油从海底架上升到了有许多大型中上层鱼类产卵的表层。在此我们描述了现场采集油样对包括蓝鳍金枪鱼,黄鳍金枪鱼和琥珀鱼在内的温水掠食动物迅速发育胚胎的影响。对于每个物种,环境相关MC252原油泄漏造成了心脏发育的严重缺陷。此

Read More

Abstract In the last decade there has been an exponential increase in knowledge about the genetic basis of complex human traits, including neuropsychi

Read More

AbstractGold mining has rapidly increased in western Amazonia, but the rates and ecological impacts of mining remain poorly known and potentially under

Read More

Abstract The interrelationships between hydrologically driven evolution of legacy landscapes downstream of major mining districts and the contaminatio

Read More

Abstract Changes in global (ocean and land) precipitation are among the most important and least well-understood consequences of climate change. Incre

Read More

AbstractAntiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of

Read More

AbstractThe biological mechanisms underlying long-term partner bonds in humans are unclear. The evolutionarily conserved neuropeptide oxytocin (OXT) is

Read More

Abstract Wine grapes present a unique biogeography model, wherein microbial biodiversity patterns across viticultural zones not only answer questions

Read More