PLOS ONE2014-02-24 5:15 PM

ABO基因型,“血型”食疗与心脏代谢风险因素 ABO Genotype, ‘Blood-Type’ Diet and Cardiometabolic Risk Factors 

论文摘要 

背景 
“血型”饮食法建议人们根据自身ABO血型选择饮食来保健和减少如心血管疾病等的慢性疾病风险。然而这种“血型饮食法”模式是否会带来健康后果尚未得到检验。本研究的目的是为了证实“血型饮食法”与心脏代谢健康的生物指标之间的关联,以及ABO基因型是否能修正任何这种关联。 

方法 
受试者(n = 1,455)来自于多伦多营养基因组学与健康研究的参与者。 
我们进行了维期1个月有关196项食物的膳食摄入量问卷评估,且对饮食进行了计算评分来证实每个“血型饮食法”的相对关联性。通过ABO基因中的基因分型rs8176719和rs8176746来测定 ABO血型。我们运用了将年龄,性别,种族,和能量摄入作为协变量的协方差分析(ANCOVA)来比较每个“血型饮食法”得分三分位数的心脏代谢生物指标。 

结果 
坚持“A型饮食法”表现为较低体质指数,腰围,血压,血清胆固醇,甘油三酯,胰岛素,HOMA-IR及HOMA-β(P <0.05)。坚持“AB饮食法” 除BMI和腰围指标之外,也表现出了较低水平的这些生物指标(P <0.05)。“O型饮食法”则与 较低的甘油三酯相关(P <0.0001)。使用相应血型所匹配的“血型饮食法”没有改变这些关联指标的影响力大小。没有发现“B型饮食法”与任何指标有显著关联。 

结论 
遵守某些“血型饮食法”可以降低某些心血管代谢危险因素,但表现出的这些关联性与个体ABO基因型无关,因此研究结果并不支持这种“血型饮食法”假说。 

Abstract 

Background 

The ‘Blood-Type’ diet advises individuals to eat according to their ABO blood group to improve their health and decrease risk of chronic diseases such as cardiovascular disease. However, the association between blood type-based dietary patterns and health outcomes has not been examined. The objective of this study was to determine the association between ‘blood-type’ diets and biomarkers of cardiometabolic health and whether an individual's ABO genotype modifies any associations. 

Methods 

Subjects (n = 1,455) were participants of the Toronto Nutrigenomics and Health study. Dietary intake was assessed using a one-month, 196-item food frequency questionnaire and a diet score was calculated to determine relative adherence to each of the four ‘Blood-Type’ diets. ABO blood group was determined by genotyping rs8176719 and rs8176746 in the ABO gene. ANCOVA, with age, sex, ethnicity, and energy intake as covariates, was used to compare cardiometabolic biomarkers across tertiles of each ‘Blood-Type’ diet score. 

Results 

Adherence to the Type-A diet was associated with lower BMI, waist circumference, blood pressure, serum cholesterol, triglycerides, insulin, HOMA-IR and HOMA-Beta (P<0.05). Adherence to the Type-AB diet was also associated with lower levels of these biomarkers (P<0.05), except for BMI and waist circumference. Adherence to the Type-O diet was associated with lower triglycerides (P<0.0001). Matching the ‘Blood-Type’ diets with the corresponding blood group did not change the effect size of any of these associations. No significant association was found for the Type-B diet. 

Conclusions 

Adherence to certain ‘Blood-Type’ diets is associated with favorable effects on some cardiometabolic risk factors, but these associations were independent of an individual's ABO genotype, so the findings do not support the ‘Blood-Type’ diet hypothesis. 

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