细胞期刊(Cell)2014-05-05 6:28 PM

二氧化碳和其他感官线索的多模式组成掌控了蚊子对人类的吸引 Multimodal Integration of Carbon Dioxide and Other Sensory Cues Drives Mosquito Attraction to Humans

论文要点
•埃及伊蚊Gr3突变体不能检测或在行为上对挥发的二氧化碳作出回应
•二氧化碳检测可使蚊子对热和乳酸作出回应
•GR3突变体可以减弱但不能消除蚊子对活体宿主的“寻猎”
•二氧化碳,热量和气味线索的多模式结合驱使了蚊子的这种“寻猎”

Highlights
•Ae. aegypti Gr3 mutants do not detect or behaviorally respond to volatile CO2
•CO2 detection can gate mosquito responses to heat and lactic acid
•Attraction to live hosts is diminished but not abolished in Gr3 mutants
•Multimodal integration of CO2, heat, and odor cues drives mosquito attraction

论文总结
自人体散发出的多感官线索被认为是吸引嗜血雌蚊的主因。要确定二氧化碳(CO2)检测对蚊子寻猎宿主行为的相对协助性,我们使埃及伊蚊的CO2受体亚基中的AaegGr3基因发生突变。Gr3突变体缺乏对CO2的电生物学和行为反应。这些突变体也无法显示CO2这种人体散发出的引诱剂对热量和乳酸的诱发反应,这表明二氧化碳可以掌控其对其他感官刺激的反应。Gr3突变体在广阔半域环境中对人类活体的吸引力只是轻微受损,而其对动物宿主的反应根据特定空间尺度的程度大大降低。热量和气味线索的协同整合可能驱使蚊子在没有二氧化碳检测情况下对宿主的寻猎行为。我们揭示了一系列的网络互动,通过二氧化碳,人体气味和热量的多模式组合构成了蚊子对人类的“寻猎”。

Summary
Multiple sensory cues emanating from humans are thought to guide blood-feeding female mosquitoes to a host. To determine the relative contribution of carbon dioxide (CO2) detection to mosquito host-seeking behavior, we mutated the AaegGr3 gene, a subunit of the heteromeric CO2 receptor in Aedes aegypti mosquitoes. Gr3 mutants lack electrophysiological and behavioral responses to CO2. These mutants also fail to show CO2-evoked responses to heat and lactic acid, a human-derived attractant, suggesting that CO2 can gate responses to other sensory stimuli. Whereas attraction of Gr3 mutants to live humans in a large semi-field environment was only slightly impaired, responses to an animal host were greatly reduced in a spatial-scale-dependent manner. Synergistic integration of heat and odor cues likely drive host-seeking behavior in the absence of CO2 detection. We reveal a networked series of interactions by which multimodal integration of CO2, human odor, and heat orchestrates mosquito attraction to humans.

KEYWORDS

SHARE & LIKE

COMMENTS

ABOUT THE AUTHOR

细胞期刊(Cell)

0 Following 3 Fans 0 Projects 125 Articles

SIMILAR ARTICLES

Epigenetic mechanisms have been proposed to play crucial roles in mammalian development, but their precise functions are only partially understood. To

Read More

Summary Replenishing insulin-producing pancreatic β cell mass will benefit both type I and type II diabetics. In adults, pancreatic β cells are gene

Read More

Summary Replenishing insulin-producing pancreatic β cell mass will benefit both type I and type II diabetics. In adults, pancreatic β cells are gene

Read More

Summary 5-methylcytosine is a major epigenetic modification that is sometimes called “the fifth nucleotide.” However, our knowledge of how offspring

Read More

Summary 5-methylcytosine is a major epigenetic modification that is sometimes called “the fifth nucleotide.” However, our knowledge of how offspring

Read More

Summary All metazoan guts are subjected to immunologically unique conditions in which an efficient antimicrobial system operates to eliminate pathog

Read More

Summary All metazoan guts are subjected to immunologically unique conditions in which an efficient antimicrobial system operates to eliminate pathog

Read More

Summary Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. I

Read More

Summary Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. I

Read More

Summary The most common form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy in the elderly. To clarify

Read More