Resveratrol, a polyphenol found in grapes, red wine, chocolate, and certain berries and roots, is considered to have antioxidant, anti-inflammatory, and anticancer effects in humans and is related to longevity in some lower organisms.
To determine whether resveratrol levels achieved with diet are associated with inflammation, cancer, cardiovascular disease, and mortality in humans.
Prospective cohort study, the Invecchiare in Chianti (InCHIANTI) Study (“Aging in the Chianti Region”), 1998 to 2009 conducted in 2 villages in the Chianti area in a population-based sample of 783 community-dwelling men and women 65 years or older.
Twenty-four–hour urinary resveratrol metabolites.
Main Outcomes and Measures
Primary outcome measure was all-cause mortality. Secondary outcomes were markers of inflammation (serum C-reactive protein [CRP], interleukin [IL]-6, IL-1β, and tumor necrosis factor [TNF]) and prevalent and incident cancer and cardiovascular disease.
平均（95％CI）对数总尿样白藜芦醇代谢物浓度为7.08（6.69-7.48）纳摩尔/克的肌氨酸酐。在随后的9年随访中，268名参加者（34.3％）死亡。按基线总尿样白藜芦醇代谢物最低到最高四分位数，参与者全因死亡的比例分别为34.4％，31.6％，33.5％和37.4％（P = 0.67）。相较于那些处于根据潜在混杂因素调整后的多变量Cox比例风险模型中的总尿样白藜芦醇的最高四分位数的参与者来说，处于最低四分位数的参与者具有的死亡率危害比为0.80（95％CI，0.54-1.17）。白藜芦醇水平与血清CRP，IL-6，IL-1β，TNF，流行或事件性心血管疾病或癌症无显著关联。
Mean (95% CI) log total urinary resveratrol metabolite concentrations were 7.08 (6.69-7.48) nmol/g of creatinine. During 9 years of follow-up, 268 (34.3%) of the participants died. From the lowest to the highest quartile of baseline total urinary resveratrol metabolites, the proportion of participants who died from all causes was 34.4%, 31.6%, 33.5%, and 37.4%, respectively (P = .67). Participants in the lowest quartile had a hazards ratio for mortality of 0.80 (95% CI, 0.54-1.17) compared with those in the highest quartile of total urinary resveratrol in a multivariable Cox proportional hazards model that adjusted for potential confounders. Resveratrol levels were not significantly associated with serum CRP, IL-6, IL-1β, TNF, prevalent or incident cardiovascular disease, or cancer.
Conclusions and Relevance
In older community-dwelling adults, total urinary resveratrol metabolite concentration was not associated with inflammatory markers, cardiovascular disease, or cancer or predictive of all-cause mortality. Resveratrol levels achieved with a Western diet did not have a substantial influence on health status and mortality risk of the population in this study.