论文摘要
Abstract
研究重要性
白藜芦醇是一种能在葡萄，红酒，巧克力和某些浆果和根茎中发现的多酚，它被认为在人体中具有抗氧化，抗炎和抗癌作用且与低等生物的长寿有关。
Importance
Resveratrol, a polyphenol found in grapes, red wine, chocolate, and certain berries and roots, is considered to have antioxidant, anti-inflammatory, and anticancer effects in humans and is related to longevity in some lower organisms.
研究目标
要确定饮食达到的白藜芦醇含量是否与人体炎症，癌症，心血管疾病和死亡有关。
Objective
To determine whether resveratrol levels achieved with diet are associated with inflammation, cancer, cardiovascular disease, and mortality in humans.
研究设计
前瞻性队列研究，即基安蒂（InCHIANTI）研究中的Invecchiare（“基安蒂地区的老龄化”），该研究于1998至2009年间在基安蒂地区2个村庄中进行，具有783名社区居住的65岁以上男性和女性构成的人口基础样本。
Design
Prospective cohort study, the Invecchiare in Chianti (InCHIANTI) Study (“Aging in the Chianti Region”), 1998 to 2009 conducted in 2 villages in the Chianti area in a population-based sample of 783 community-dwelling men and women 65 years or older.
研究公布
二十四小时尿样白藜芦醇代谢物。
Exposures
Twenty-four–hour urinary resveratrol metabolites.
主要成果和措施
主要成果指标为全因死亡率。次要成果是炎症标志物（血清C-反应蛋白[CRP],白介素[IL]-6,IL-1β以及肿瘤坏死因子[TNF]）与流行和事故性癌症以及心血管疾病。
Main Outcomes and Measures
Primary outcome measure was all-cause mortality. Secondary outcomes were markers of inflammation (serum C-reactive protein [CRP], interleukin [IL]-6, IL-1β, and tumor necrosis factor [TNF]) and prevalent and incident cancer and cardiovascular disease.
研究结果
平均（95％CI）对数总尿样白藜芦醇代谢物浓度为7.08（6.69-7.48）纳摩尔/克的肌氨酸酐。在随后的9年随访中，268名参加者（34.3％）死亡。按基线总尿样白藜芦醇代谢物最低到最高四分位数，参与者全因死亡的比例分别为34.4％，31.6％，33.5％和37.4％（P = 0.67）。相较于那些处于根据潜在混杂因素调整后的多变量Cox比例风险模型中的总尿样白藜芦醇的最高四分位数的参与者来说，处于最低四分位数的参与者具有的死亡率危害比为0.80（95％CI，0.54-1.17）。白藜芦醇水平与血清CRP，IL-6，IL-1β，TNF，流行或事件性心血管疾病或癌症无显著关联。
Results
Mean (95% CI) log total urinary resveratrol metabolite concentrations were 7.08 (6.69-7.48) nmol/g of creatinine. During 9 years of follow-up, 268 (34.3%) of the participants died. From the lowest to the highest quartile of baseline total urinary resveratrol metabolites, the proportion of participants who died from all causes was 34.4%, 31.6%, 33.5%, and 37.4%, respectively (P = .67). Participants in the lowest quartile had a hazards ratio for mortality of 0.80 (95% CI, 0.54-1.17) compared with those in the highest quartile of total urinary resveratrol in a multivariable Cox proportional hazards model that adjusted for potential confounders. Resveratrol levels were not significantly associated with serum CRP, IL-6, IL-1β, TNF, prevalent or incident cardiovascular disease, or cancer.
相关结论
在较早社区居住的成年人的总尿样白藜芦醇代谢物浓度与炎症标志物，心血管疾病或癌症或全因死亡率预测无关联。在此研究中，西方饮食所达到的白藜芦醇含量对人口健康状况和死亡风险没有实质性的影响。
Conclusions and Relevance
In older community-dwelling adults, total urinary resveratrol metabolite concentration was not associated with inflammatory markers, cardiovascular disease, or cancer or predictive of all-cause mortality. Resveratrol levels achieved with a Western diet did not have a substantial influence on health status and mortality risk of the population in this study.