Nature2014-06-09 3:19 PM

细胞衰老与衰老过程的关系 The role of senescent cells in ageing

论文摘要

我们对衰老细胞的基础生物学相对来说知之甚少,尤其是在活体中,但越来越多的证据表明,细胞衰老在衰老中起一定作用,同时与年龄相关的疾病也刺激了人们对这一话题的兴趣。Jan van Deursen对最近有关衰老细胞在衰老中所起作用的研究工作进行了综述。新的发现表明,衰老并不是一个静态的细胞终点。相反,它是与组织修复和癌症以及衰老过程相关的一系列动态细胞状态。van Deursen进而对怎样利用不断出现的新信息来选择性清除有害的衰老细胞群以延长健康寿命的问题进行了讨论。

Abstract 

Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights indicate that, unlike a static endpoint, senescence represents a series of progressive and phenotypically diverse cellular states acquired after the initial growth arrest. A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.

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