Science2014-06-13 6:37 PM

GDF11蛋白可逆转小鼠衰老迹象 Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

论文摘要 

Science上两项研究以两种方式检测了 GDF11 的影响。研究人员利用了所谓的联体生活系统,将两只小鼠通过手术连接在一起,年轻小鼠的血液循环通过老年的小鼠。第二项研究是给年老小鼠注入了 GDF11 。这些研究发现GDF11能使老龄鼠肌肉中的干细胞恢复活力,增强老龄鼠的体质,延长它们的寿命。

Abstract 

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors. Age-related decline of neurogenesis and cognitive function is associated with reduced blood flow and decreased numbers of neural stem cells. Therefore, restoring the functionality of the niche should counteract some of the negative effects of aging. We show that factors found in young blood induce vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination in aging mice. Further, we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis. The identification of factors that slow the age-dependent deterioration of the neurogenic niche in mice may constitute the basis for new methods of treating age-related neurodegenerative and neurovascular diseases.

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