Science2014-06-13 6:52 PM

两篇Science文章:发现助推“返老还童”蛋白 Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

论文摘要 

这篇文章与上篇文章是同系列文章,研究人员注入一种称作为 GDF11 的蛋白质( GDF11 存在小鼠和人类之中),可以改善年龄相当于70岁老人的老年小鼠的运动能力,并提高老龄小鼠大脑嗅觉区的功能——它们能够像年轻小鼠一样识别气味。研究人员表示,不出意外的话,他们期望能够在3-5年内推动 GDF11 进入人类临床试验。

Abstract 

Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by exposure to a young circulation, suggesting that young blood contains humoral “rejuvenating” factors that can restore regenerative function. Here, we demonstrate that the circulating protein growth differentiation factor 11 (GDF11) is a rejuvenating factor for skeletal muscle. Supplementation of systemic GDF11 levels, which normally decline with age, by heterochronic parabiosis or systemic delivery of recombinant protein, reversed functional impairments and restored genomic integrity in aged muscle stem cells (satellite cells). Increased GDF11 levels in aged mice also improved muscle structural and functional features and increased strength and endurance exercise capacity. These data indicate that GDF11 systemically regulates muscle aging and may be therapeutically useful for reversing age-related skeletal muscle and stem cell dysfunction.

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