Nature2014-06-18 5:48 PM

“受孕蛋白”Juno在卵子中被发现 Juno is the egg Izumo receptor and is essential for mammalian fertilization

论文摘要 

我们对精子和卵子怎样专一地相互识别知之甚少。雄性生育所需的一种精子细胞表面蛋白(名叫Izumo)于2005年被发现,但其在卵子上的伙伴的身份此前却仍不清楚。现在,Gavin Wright及同事识别出了Izumo的卵子受体,他们将其称之为Juno。没有Juno的雌性小鼠是不育的,缺少Juno的卵子不与正常精子融合。作者发现这种相互作用在哺乳动物中都保留了下来,所以这些发现也许能为新的生育治疗方法和避孕药物的开发提供可能的机会。

Abstract 

Fertilization occurs when sperm and egg recognize each other and fuse to form a new, genetically distinct organism. The molecular basis of sperm–egg recognition is unknown, but is likely to require interactions between receptor proteins displayed on their surface. Izumo1 is an essential sperm cell-surface protein, but its receptor on the egg has not been described. Here we identify folate receptor 4 (Folr4) as the receptor for Izumo1 on the mouse egg, and propose to rename it Juno. We show that the Izumo1–Juno interaction is conserved within several mammalian species, including humans. Female mice lacking Juno are infertile and Juno-deficient eggs do not fuse with normal sperm. Rapid shedding of Juno from the oolemma after fertilization suggests a mechanism for the membrane block to polyspermy, ensuring eggs normally fuse with just a single sperm. Our discovery of an essential receptor pair at the nexus of conception provides opportunities for the rational development of new fertility treatments and contraceptives.

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