Nature2014-06-19 3:59 PM

维生素A 是后代免疫所需的 Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

论文摘要 

对吃完全不含维生素A的食物与吃维生素A含量低和高的食物的怀孕小鼠所做的对比,显示了母方的维生素A代谢物(主要是视黄酸)在建立发育中的胎儿的先天免疫系统中所起的作用。这种维生素是胚胎发育过程中次级淋巴器官的形成所需的,影响后代成年后的免疫能力。

Abstract 

The impact of nutritional status during fetal life on the overall health of adults has been recognized; however, dietary effects on the developing immune system are largely unknown. Development of secondary lymphoid organs occurs during embryogenesis and is considered to be developmentally programmed. Secondary lymphoid organ formation depends on a subset of type 3 innate lymphoid cells (ILC3) named lymphoid tissue inducer (LTi) cells. Here we show that mouse fetal ILC3s are controlled by cell-autonomous retinoic acid (RA) signalling in utero, which pre-sets the immune fitness in adulthood. We found that embryonic lymphoid organs contain ILC progenitors that differentiate locally into mature LTi cells. Local LTi cell differentiation was controlled by maternal retinoid intake and fetal RA signalling acting in a haematopoietic cell-autonomous manner. RA controlled LTi cell maturation upstream of the transcription factor RORγt. Accordingly, enforced expression of Rorgt restored maturation of LTi cells with impaired RA signalling, whereas RA receptors directly regulated the Rorgt locus. Finally, we established that maternal levels of dietary retinoids control the size of secondary lymphoid organs and the efficiency of immune responses in the adult offspring. Our results reveal a molecular link between maternal nutrients and the formation of immune structures required for resistance to infection in the offspring.

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