Nature2014-06-24 3:41 PM

骨头生长与血管形成有关 Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone


有证据表明,血管 (尤其是它们的内皮细胞) 控制器官的生长、平衡和再生。在本期Nature上发表的两篇论文中,Ralf Adams及同事证明,骨头血管含有专门支持骨成熟和再生的内皮细胞。Anjali Kusumbe等人在小鼠骨骼系统内识别出一个在介导骨生长中起关键作用的毛细血管亚型。这些血管含有所谓的 “H-型内皮细胞”,它们优先与骨祖细胞关联,在衰老过程中数量减少。Hypoxia-inducible factor 1 (HIF-1) 被发现在维持 “H-型内皮细胞”中非常关键,同时这些细胞在衰老的动物体内失去的事实表明,HIF-1 信号作用的失去也许参与了与年龄相关的骨变化。在第二篇论文中,Saravana Ramasamy等人发现,骨头中的血管生长需要Notch信号作用,并且涉及一种专门形式的血管发生,后者不涉及内皮幼芽。


The mammalian skeletal system harbours a hierarchical system of mesenchymal stem cells, osteoprogenitors and osteoblasts sustaining lifelong bone formation. Osteogenesis is indispensable for the homeostatic renewal of bone as well as regenerative fracture healing, but these processes frequently decline in ageing organisms, leading to loss of bone mass and increased fracture incidence. Evidence indicates that the growth of blood vessels in bone and osteogenesis are coupled, but relatively little is known about the underlying cellular and molecular mechanisms. Here we identify a new capillary subtype in the murine skeletal system with distinct morphological, molecular and functional properties. These vessels are found in specific locations, mediate growth of the bone vasculature, generate distinct metabolic and molecular microenvironments, maintain perivascular osteoprogenitors and couple angiogenesis to osteogenesis. The abundance of these vessels and associated osteoprogenitors was strongly reduced in bone from aged animals, and pharmacological reversal of this decline allowed the restoration of bone mass.






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