University of Rochester2014-08-04 2:41 PM

Early Postnatal Exposure to Ultrafine Particulate Matter Air Pollution: Persistent Ventriculomegaly, Neurochemical Disruption, and Glial Activation Preferentially in Male Mice

Abstract


Background

Air pollution has been associated with adverse neurological and behavioral health effects in children and adults. Recent studies link air pollutant exposure to adverse neurodevelopmental outcomes, including increased risk for autism, cognitive decline, ischemic stroke, schizophrenia, and depression.


Objectives

This study sought to investigate the mechanism(s) by which exposure to concentrated ambient ultrafine particles (CAPS) adversely influence central nervous system (CNS) development.


Methods

C57Bl6/J mice were exposed to ultrafine (<100 nm) CAPS using the Harvard University Concentrated Ambient Particle System or filtered air postnatal days (PND) 4-7 and 10-13 after which animals were euthanized either 24 hours or 40 days following cessation of exposure, and in another group of males at 270 days (ventricle area). Lateral ventricle area, glial activation, CNS cytokines, and monoamine and amino acid neurotransmitters were quantified.


Results

 CAPS induced ventriculomegaly (i.e., lateral ventricle dilation) preferentially in male mice that persisted through young adulthood. Additionally, CAPS-exposed males generally showed decreases in developmentally important CNS cytokines, whereas, in females, CAPS induced a neuroinflammatory response as indicated by increases in CNS cytokines. CAPS also induced changes in CNS neurotransmitters and glial activation across multiple brain regions in a sex-dependent manner and increases hippocampal glutamate in males.


Conclusions

CAPS induces brain region- and sex-dependent alterations in cytokines and neurotransmitters in both males and females. Lateral ventricle dilation (i.e., ventriculomegaly) is only observed in CAPS-exposed male mice. Ventriculomegaly is a neuropathology that has been associated with poor neurodevelopmental outcome, autism, and schizophrenia. Our findings suggest alteration of developmentally important neurochemicals and lateral ventricle dilation may be mechanistically related to observations linking ambient air pollutant exposure and adverse neurological/neurodevelopmental outcome in humans.


Full Article:

http://ehp.niehs.nih.gov/1307984/

KEYWORDS

SHARE & LIKE

COMMENTS

ABOUT THE AUTHOR

University of Rochester

0 Following 0 Fans 0 Projects 6 Articles

SIMILAR ARTICLES

AbstractThe transition zone between the modern northern and southern Appalachian Mountains is located in Pennsylvania, where the structural orientation

Read More

AbstractImportance  Mothers and children living in adverse contexts are at risk of premature death.Objective  To determine the effect of prenatal and i

Read More

AbstractHuman decision-makers often exhibit the hot-hand phenomenon, a tendency to perceive positive serial autocorrelations in independent sequential

Read More

AbstractThis paper investigates engagement (E), alignment (A), and rigor (R) as vital signs of high-quality teacher instruction as measured by the EAR

Read More

AbstractBackgroundAir pollution has been associated with adverse neurological and behavioral health effects in children and adults. Recent studies link

Read More

ABSTRACTInteraction between a central outflow and a surrounding wind is common in astrophysical sources powered by accretion. Understanding how the int

Read More