University of Rutgers2014-10-29 1:20 PM

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

Abstract

Type 2 diabetes (T2D) has reached an epidemic level globally. Most current treatments ameliorate the hyperglycemic symptom of the disease but are not effective in correcting its underlying cause. One important causal factor of T2D is ectopic accumulation of lipids in metabolically sensitive organs such as liver and muscle. Mitochondrial uncoupling, which reduces cellular energy efficiency and increases lipid oxidation, is an appealing therapeutic strategy. The challenge, however, is to discover safe mitochondrial uncouplers for practical use. Niclosamide is an anthelmintic drug approved by the US Food and Drug Administration that uncouples the mitochondria of parasitic worms. Here we show that niclosamide ethanolamine salt (NEN) uncouples mammalian mitochondria at upper nanomolar concentrations. Oral NEN increases energy expenditure and lipid metabolism in mice. It is also efficacious in preventing and treating hepatic steatosis and insulin resistance induced by a high-fat diet. Moreover, it improves glycemic control and delays disease progression in db/db mice. Given the well-documented safety profile of NEN, our study provides a potentially new and practical pharmacological approach for treating T2D.


Full Article

KEYWORDS

SHARE & LIKE

COMMENTS

ABOUT THE AUTHOR

University of Rutgers

0 Following 0 Fans 0 Projects 6 Articles

SIMILAR ARTICLES

AbstractA major task across infancy is the creation and tuning of the acoustic maps that allow efficient native language processing. This process cruci

Read More

AbstractThe authors examined associations between marital quality and both general life satisfaction and experienced (momentary) well-being among older

Read More

AbstractHighlights•We report two distinct neural mechanisms for persistence through adversity•Perceiving control over setbacks increases persistence•St

Read More

Highlights-EIH profile in rats, can predict pain severity following nerve injury.-EIH profile is associated with mechanical and thermal sensitivity in

Read More

AbstractType 2 diabetes (T2D) has reached an epidemic level globally. Most current treatments ameliorate the hyperglycemic symptom of the disease but a

Read More