Johns Hopkins University2014-11-21 4:48 PM

Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid

Abstract

Lubrication is key for the efficient function of devices and tissues with moving surfaces , such as articulating joints, ocular surfaces and the lungs . 


Indeed , lubrication dysfunction leads to increased friction and degeneration of these systems. Here , we present a polymer–peptide surface coating platform to non-covalently bind hyaluronic acid (HA) , a natural lubricant in the body . Tissue surfaces treated with the HA-binding system exhibited higher lubricity values , and in vivo were able to retain HA in the articular joint and to bind ocular tissue surfaces .


 Biomaterials-mediated strategies that locally bind and concentrate HA could provide physical and biological benefits when used to treat tissue-lubricating dysfunction and to coat medical devices .



Full Article:

http://www.nature.com/nmat/journal/v13/n10/abs/nmat4048.html

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