Lubrication is key for the efficient function of devices and tissues with moving surfaces , such as articulating joints, ocular surfaces and the lungs .
Indeed , lubrication dysfunction leads to increased friction and degeneration of these systems. Here , we present a polymer–peptide surface coating platform to non-covalently bind hyaluronic acid (HA) , a natural lubricant in the body . Tissue surfaces treated with the HA-binding system exhibited higher lubricity values , and in vivo were able to retain HA in the articular joint and to bind ocular tissue surfaces .
Biomaterials-mediated strategies that locally bind and concentrate HA could provide physical and biological benefits when used to treat tissue-lubricating dysfunction and to coat medical devices .